BIOM-40. COMPARATIVE STUDY OF INFLAMMATORY MARKERS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH GLIOMA AND CENTRAL NERVOUS SYSTEM MALIGNANT LYMPHOMA

Abstract INTRODUCTION Cytokines in the cerebrospinal fluid (CSF) are useful as markers for primary central nervous system malignant lymphoma (PCBSL). However, there few reports of CSF glioma. We analyzed and examined glioma PCNSL inflammation-related mediators. MATERIALS AND METHODS The patients with who were operated on at Kobe University between 2006 2017 whose histology was diagnosed, stored -80 °C before treatment. Using Bio-Plex Pro Human Inflammation Assays (Bio-Rad Laboratories, Inc.), 37 types molecules such TNF superfamilies, interferonss, Interleukines measured compared PCNSL. RESULTS subjects 53 24 patients. There 22 significant differences PCNSL, 18 high 4 In addition to IL-10, which has been reported so far, higher concentrations found Osteopontin, TNFSF8, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, sTNF-R1, sTNF-R2, IL-6Ra, IL-8, IL-12(p40), IL-20, IL-27, sCD163, MMP2, MMP3, CHI3L1. On other hand, IL-2, Il-12(p70), IL-22, MMP-1 levels Although CD163 is an important molecule a marker M2 macrophages, immunostaining tissues showed no difference infiltration Glioblastoma This suggests that macrophages infiltrating have different activation states. CONCLUSION had inflammatory mediators TNF-related molecules. significantly sCD163 than glioblastoma, suggesting intratumoral macrophages.